Fig. 2

Regions of increased chromatin accessibility in Setd8 mutant cells compared to controls. a Heat map of normalized chromatin accessibility in Setd8 mutant and control erythroblasts. b Genomic distribution of regions more accessible in Setd8 mutant cells and all accessible regions identified compared to the overall composition of the whole genome. c Significantly enriched pathways based on genes co-located with regions of more accessible chromatin. d–e Chromatin accessibility at the Gata2 and Gata1 loci. At the Gata2 locus, there is a region of increased chromatin accessibility in Setd8 mutant erythroblasts that is associated with increased mRNA expression. In contrast, chromatin accessibility and mRNA expression at the Gata1 locus is similar in Setd8 mutant and control samples