Fig. 2
From: Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation
The effects of BET inhibition on melanin synthesis is dose dependent and reversible. a Melb-a cells were differentiated for 48 h in the presence of vehicle (VC) or (+)JQ1 at the indicated concentrations. Cells were pelleted and photographed. b Melanin assays were performed on cells shown in a. The results are the average of three independent experiments. Standard error bars are shown. Statistically significant differences between VC and different concentrations of (+)JQ1 are shown (*p < 0.05, **p < 0.01, ***p < 0.001). c Melb-a cells were differentiated for 72 h in the presence of inactive (−)JQ1 or active (+)JQ1 (500 nM) (top). Cells from (+)JQ1 treated samples were washed and passaged into differentiation media containing inactive (−)JQ1 or active (+)JQ1 and further cultured for the indicated number of days (bottom)