Fig. 6

Compendium of results. Dual-gradient heatmaps depicting the percentage differences relative to F1 Veh control mice in each outcome measure (vertical axis) and brain region (horizontal axis) for F1 NIC (left) and F2 NIC (right) mice. A percentage difference of zero indicates no difference (depicted in gray) relative to F1 Veh control mice, whereas percentage differences of − 60% and 160% indicate a 60% decrease (depicted in red) and a 160% increase (depicted in green), respectively, relative to F1 Veh control mice. F1 NIC first-generation developmental nicotine-exposed adolescent offspring, F2 NIC second-generation developmental nicotine-exposed adolescent offspring, FCX frontal cortices, STR striata, HIPP hippocampi, DNMT3A DNA methyltransferase 3A, TET2 ten-eleven translocase methylcytosine dioxygenase 2, MeCP2 methyl-CpG-binding protein 2, pMeCP2 phospho-MeCP2 (Ser⁴²¹), HDAC2 histone deacetylase 2, pHDAC2 phospho-HDAC2 (Ser³⁹⁴). *p < 0.05; **p < 0.01; ***p < 0.001