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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice

Fig. 3

DNE does not impact TET2 content in the frontal cortices, striata, or hippocampi. Representative Western blot images and densitometric measurements of TET2 abundance in frontal cortices (nF1Veh = 7, nF1NIC = 8, and nF2NIC = 10), striata (nF1Veh = 7, nF1NIC = 9, and nF2NIC = 9), and hippocampi (nF1Veh = 8, nF1NIC = 9, and nF2NIC = 8). a TET2 abundance in frontal cortices. Frontal cortical TET2 content is unaltered in F1 NIC and F2 NIC mice. b TET2 abundance in striata. Striatal TET2 content is unaltered in F1 NIC and F2 NIC mice. c TET2 abundance in hippocampi. Hippocampal TET2 content is unaltered in F1 NIC and F2 NIC mice. FCX frontal cortices, STR striata, HIPP hippocampi, TET2 ten-eleven translocase methylcytosine dioxygenase 2, TET2 (1) TET2 isoform 1, TET2 (2) TET2 isoform 2, TET2 (3) TET2 isoform 3, TBP TATA-binding protein. All data are mean ± SEM

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