Fig. 7
From: JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability
Model of the role of JMJD1B in histone H3 and H4 processing pathway. We propose that JMJD1B regulates the degradation of tNASP, thus in the absence of JMJD1B, tNASP is not degraded by the proteasome and its protein level increases. As a consequence, histones H3 and H4 accumulate early in the maturation pathway, leading to chromatin assembly defects, which could impact into G2/M arrest, DNA damage and genome instability