Fig. 6

Genomic instability in patients with cancer having high incidence of mutations in the JMJD1B gene. Mutations in JMJD1B were mapped in the scheme in panel A according to their location in the gene with respect to the Jumanji domain as colored boxes: point mutations (white), insertions (IN: green) and deletions (DEL: blue). When mutations occurred in both the Jumanji domain (orange) and regions of the gene outside the domain (gray), the scheme is highlighted in yellow, regardless of the type of mutation. Color-coding used in the scheme was also applied to the symbols representing the data points in the graphs in panels B to E. The global genomic instability index was calculated as indicated in “Methods”. For each cancer type, data derived from healthy tissue (blood and/or solid tissue samples) and primary tumor biopsies was analyzed in the JMJD1B-mutants patient population. The cancer datasets considered were: KIRC (kidney renal clear cell carcinoma), ACC (adrenocortical carcinoma), OV (ovarian cancer) and UCEC (uterine corpus endometrial cancer). Missing datasets are highlighted in gray