Skip to main content
Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans

Fig. 5

Extra-TFIIIC sites reside in LEM-2-associated domains. a Two hypothetical scenarios in which extra-TFIIIC sites associate with the nuclear periphery. b Fraction of TFIIIC sites overlapping 223 NPP-13-binding sites (± 500 bp of NPP-13 site center) defined by Ikegami and Lieb [49]. Permutations of TFIIIC sites were performed within chromosomal domains (i.e., center and left/right arms). P, empirical P-value based on the 2000 permutations. c Distribution of TFIIIC sites and LEM-2 subdomains defined by Ikegami et al. [28]. d Fraction of TFIIIC sites overlapping LEM-2 subdomains and gaps of various sizes between LEM-2 subdomains. Permutations and P-value computation are performed as in b. e Model for chromosomal organization where extra-TFIIIC sites are clustered in the autosome arms corresponding LEM-2 domains and intersperse H3K9me3-enriched regions

Back to article page