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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans

Fig. 4

Extra-TFIIIC sites are located adjacent to H3K9me3-enriched regions. a Distribution of TFIIIC sites and H3K9me2-enriched regions. b Distribution of TFIIIC sites and H3K9me3-enriched regions. c (top) Two representative genomic regions showing extra-TFIIIC sites interspersing H3K9me3-enriched regions. (bottom) Genomic regions shown in rectangles in the top panels. d Fraction of TFIIIC sites overlapping H3K9me2/H3K9me3-enriched regions. Because the H3K9me2/H3K9me3-enriched regions are infrequent in the X chromosome, the X chromosome is plotted separately. Permutations of TFIIIC sites were performed within chromosomal domains (i.e., center and left/right arms). P, empirical P-value based on the 2000 permutations. e Distance between TFIIIC site center and H3K9me2- (left) or H3K9me3-enriched (left) regions. Obs the observed distance. Shuf, distance between a permutated set of TFIIIC sites and H3K9me2-enriched regions. Permutation was performed within chromosomal domains

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