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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans

Fig. 2

Extra-TFIIIC sites do not reside in protein-coding gene promoters or enhancers. a Distance between TFIIIC site center and the transcription start site (TSS) of protein-coding genes. Obs the observed distance. Shuf, the distance of a permutated set of TFIIIC sites (one permutation within chromosomes) to TSS. b Fraction of TFIIIC sites located in exons, introns, and 3′-UTRs of protein-coding genes. Permutations of TFIIIC sites were performed within chromosomal domains (i.e., center and left/right arms). P, empirical P-value based on the 2000 permutations. c Chromatin state annotation of TFIIIC sites. The chromatin state annotation reported by Evans et al. [4] is used. Permutations and P-value computation are performed as in b. d Number of TFIIIC sites resided in the three transcription-related domains reported by Evans et al. [4]. Permutations and P-value computation are performed as in b. d H3K4me3, H3K27ac, H3K4me1, and RNA polymerase II (Pol II) fold-enrichment scores (FE) at TFIIIC sites

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