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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans

Fig. 1

Identification of extra-TFIIIC sites in the C. elegans genome. a A schematic of the RNA polymerase III transcriptional machinery. b C. elegans TFIIIC complex proteins and their yeast and human orthologs for reference. c Correlation between TFTC-3 and TFTC-5 ChIP-seq fold enrichment (FE) scores at the 1658 TFTC-3-binding sites. The 1029 high-confident TFIIIC sites are indicated. d A representative genomic region showing extra-TFIIIC sites and Pol III-bound TFIIIC sites. e TFTC-3 and Pol III (RPC-1) FE scores at the 1029 TFIIIC sites. r, Pearson correlation coefficient within the TFIIIC subclasses. f TFTC-3, TFTC-5, Pol III (RPC-1), TBP (TBP-1) ChIP-seq FE signals at extra- and Pol III-bound TFIIIC sites. g Fraction of TFIIIC sites harboring the transcription start site of non-coding RNA genes within ± 100 bp of the TFIIIC site center. Dotted lines indicate non-coding RNA gene classes found in ≥ 10 TFIIIC sites. Pol III-TFIIIC, Pol III-bound TFIIIC sites. h DNA sequence motifs found in ± 75 bp of TFIIIC site centers. i Fraction of TFIIIC sites overlapping repetitive elements. P, empirical P-value based on 2000 permutations of the extra- or Pol III-bound TFIIIC sites within chromosomes. Dotted lines indicate repetitive element classes with P < 0.001

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