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Fig. 10 | Epigenetics & Chromatin

Fig. 10

From: Nickel-induced transcriptional changes persist  post exposure through epigenetic reprogramming

Fig. 10

Proposed model for the post-nickel-exposure transcriptional changes. In the untreated cells, Gene X, a potential chromatin regulator, is transcriptionally silent. However, Gene X promoter is enriched for H3K4me3 and possibly exists in a poised chromatin environment. Gene Y, also a transcriptionally silent gene, has low H3K4me3 levels and exists in a repressive chromatin environment. Nickel exposure induces the first wave of transcription, where it persistently activates Gene X, probably through induction of an upstream transcriptional regulator and/or through resolution of bivalency by inducing loss of repressive chromatin modifications. However, the protein encoded by Gene X (Protein X [red]) remains inactive in the presence of Ni2+ ions either due to inhibition of its enzymatic activity or through alteration of its DNA-binding affinity. Upon Ni wash-out, Protein X [green] is rendered active and initiates a second wave of transcription by altering the chromatin environment of Gene Y, which gains H3K4me3 and is transcriptionally activated (Protein Y)

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