Fig. 4

Comparative analysis of enhancer sites and gene expression across EC types. a PCA plot of EC samples based on H3K27ac read density fitted by generalized linear models. The color of samples indicates EC types. Samples from the upper body are circled. b A k-means clustering (k = 6) analysis of DEs (upper) and DEGs (lower) across EC types (a representative for each type) based on Z-scores. The example genes and related GO terms obtained by Metascape [67] for DEG clusters are also shown. c Read distribution of H3K4me3 (green) and H3K27ac (orange) for the genes highlighted in red in b