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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: The distributions of protein coding genes within chromatin domains in relation to human disease

Fig. 1

Distributions of the distances from the TSSs of the genes to their corresponding closest TAD borders. If the TSS is not within a TAD, the distance is calculated to the closest TAD border. Negative and positive distances correspond to TSSs inside and outside TADs, respectively. The vertical black line represents the TAD borders. Two different distributions are shown in the main plot where genes associated and non-associated with disease are represented in blue and salmon color, respectively. An abrupt enrichment of TSSs is observed within TADs starting at a distance of − 4500 nt within TADs (indicated with a vertical red line). The portion of the genome within TADs is 55% (see "Methods"). Each bin of the histogram represents 500 nt. Inset: the density for the same data is shown. Even if TSSs have a preference toward the TAD borders, the preference is lower for genes associated with disease (p-value = 7.37 × \(10^{-10}\), Wilcoxon rank test)

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