BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex—a tumour suppressor or tumour-promoting factor?

Table 2 The alterations of BRM and BRG1 in various cancers

Cancer type	SMARCA2/BRM		Refs.	SMARCA4/BRG1		Refs.
Cancer type	Protein expression	Genetic alterations	Refs.	Protein expression	Genetic alterations	Refs.
Rhabdoid tumours	↓ (concomitant INI1 loss)	Epigenetic silencing	[63, 121]	↓	Epigenetic silencing	[121, 163,164,165]
Lung cancer	↓	Promoter polymorphism	[64,65,66,67]	↓/(loss)	Mutations (LOF)	[31, 64, 166, 167]
Renal cell carcinoma (RCC)	↓	Mutations	[72,73,74]	Concomitant loss with INI1 in rhabdoid subtype	n/d	[168]
Gastric cancer	↓	n/d	[78, 79]	Normal/↑	n/d	[78, 169]
Pancreatic cancer	↑/↓	n/d	[57, 80, 81]	↑?	n/d	[80]
Hepatocellular cancer	↓	Promoter polymorphism	[82, 83]	↑	n/d	[82]
HNSCC	↓	n/d	[84]	n/d	n/d	–
ACC	↑	n/d	[86]	Normal	n/d	[86]
Oral cancer	n/d	n/d	–	↑	Not determined	[170]
Breast cancer	↑/↓	Not determined	[88, 89]	↑	2%	[88, 171]
SCCOHT	↓(loss)	n/d	[100, 101]	↓/(loss)	Somatic and germline mutations	[95,96,97,98,99]
OCCC	↓/↑^a	Mutations	[102]	n/d	n/d	–
Endometrial cancer	↓	Mutations	[105]	↓	Mutations	[105]
Prostate cancer	↓	n/d	[106, 107]	↑	n/d	[106, 107]
Melanoma	n/d	n/d	–	↑	Rare mutations	[172, 173]
NMSC	↓	Mutations	[108]	↓	n/d	[108]

ISSN: 1756-8935