Cancer type | SMARCA2/BRM | Refs. | SMARCA4/BRG1 | Refs. | ||
---|---|---|---|---|---|---|
Protein expression | Genetic alterations | Protein expression | Genetic alterations | |||
Rhabdoid tumours | ↓ (concomitant INI1 loss) | Epigenetic silencing | ↓ | Epigenetic silencing | ||
Lung cancer | ↓ | Promoter polymorphism | ↓/(loss) | Mutations (LOF) | ||
Renal cell carcinoma (RCC) | ↓ | Mutations | Concomitant loss with INI1 in rhabdoid subtype | n/d | [168] | |
Gastric cancer | ↓ | n/d | Normal/↑ | n/d | ||
Pancreatic cancer | ↑/↓ | n/d | ↑? | n/d | [80] | |
Hepatocellular cancer | ↓ | Promoter polymorphism | ↑ | n/d | [82] | |
HNSCC | ↓ | n/d | [84] | n/d | n/d | – |
ACC | ↑ | n/d | [86] | Normal | n/d | [86] |
Oral cancer | n/d | n/d | – | ↑ | Not determined | [170] |
Breast cancer | ↑/↓ | Not determined | ↑ | 2% | ||
SCCOHT | ↓(loss) | n/d | ↓/(loss) | Somatic and germline mutations | ||
OCCC | ↓/↑a | Mutations | [102] | n/d | n/d | – |
Endometrial cancer | ↓ | Mutations | [105] | ↓ | Mutations | [105] |
Prostate cancer | ↓ | n/d | ↑ | n/d | ||
Melanoma | n/d | n/d | – | ↑ | Rare mutations | |
NMSC | ↓ | Mutations | [108] | ↓ | n/d | [108] |