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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex—a tumour suppressor or tumour-promoting factor?

Fig. 4

Cancer treatment related to BRM protein. Ideas for utilising BRM in anticancer therapy are emerging. Such therapies, taken currently into consideration, are based on BRM level restoration by, e.g. HDAC inhibitors and E2F inhibitors. A very promising but demanding idea is based on a synthetic lethality approach, targeted against BRM ATPase domain or bromodomain

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Epigenetics & Chromatin

ISSN: 1756-8935