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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington’s Disease Monkey pluripotent stem cells

Fig. 5

RNA-seq revealed dysregulation of p53 signaling and cell-cycle pathways across HD differentiation. a p53 signaling pathway diagram showing DE genes (in purple) in HD cells at any stage of astrocyte differentiation. b Heatmap depicting 38 DE genes in the p53 signaling pathway at each stage of differentiation. Red indicates increased expression in HD cells and blue indicates reduced expression in HD cells. Each row corresponds to the same gene and gene names are displayed to the right of the plot. cf Cross-sectional GSEA enrichment plots. For GSEA plots, the black lines indicate the position of pathway genes in the expression data rank-sorted between HD and WT samples. Red dots indicate leading edge genes. q values are FDR corrected p values with alpha = 0.02, or the equivalent. g Diagram of the KEGG cell-cycle pathway showing genes DE (purple) in HD cells. h Heatmap depicting 54 DE cell-cycle genes in the p53-signaling pathway at each stage of differentiation. Red indicates increased expression in HD cells and blue indicates reduced expression in HD cells. Each row corresponds to the same gene and gene names are displayed to the right of the plot

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