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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Fig. 6

a MTX induced Myelomeningocele in C57BL/6 mouse embryos at 13.5 day. b Folate content in brain serum of normal and MTX-induced mouse NTDs was harvested at E13.5, and analyzed by Elisa. Data are mean ± S.D. (n = 3). *P < 0.05, by Student’s t test. c Cranial neural tissue of normal and MTX-induced mouse NTDs was harvested at E 13.5, and analyzed by western blot. Aliquots of total lysates were immunoblotted to indicate antibody. d Neural precursor marker genes cdx2, nestin, pax6, gata4 and mdm2 extracted mRNA in cranial neural tissue of MTX-induced mouse NTDs was measured by RT-qPCR. Data are mean ± S.D (n = 3). *P < 0.05, by Student’s t test

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Epigenetics & Chromatin

ISSN: 1756-8935