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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Fig. 1

a Low folate and MTX induced craniorachischisis in C57BL/6 mouse embryos at 13.5 day. b Control vs MTX treatment in mESC. The total RNA was analyzed using RNA-seq. A total of DEGs showing differential expression were identified in the APN-treatment group (P < 0.01). c Unsupervised hierarchical clustering of MTX-treated cells. d DEGs have a statistically significant change with RNA-seq analysis. e NTC-related genes Cdx2, Nestin, Pax6 and Gta4 mRNA extracted from mESCs treated with MTX was assessed by RT-qPCR. MTX 1 μM, 12 h. GAPDH was used as control. Data are shown as mean (n = 3). *P < 0.05, by Student’s t test

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