TY - JOUR AU - Greene, N. D. AU - Copp, A. J. PY - 2014 DA - 2014// TI - Neural tube defects JO - Annu Rev Neurosci VL - 37 UR - https://doi.org/10.1146/annurev-neuro-062012-170354 DO - 10.1146/annurev-neuro-062012-170354 ID - Greene2014 ER - TY - JOUR AU - Marean, A. AU - Graf, A. AU - Zhang, Y. AU - Niswander, L. PY - 2011 DA - 2011// TI - Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival JO - Hum Mol Genet VL - 20 UR - https://doi.org/10.1093/hmg/ddr289 DO - 10.1093/hmg/ddr289 ID - Marean2011 ER - TY - JOUR AU - Stover, P. J. PY - 2009 DA - 2009// TI - One-carbon metabolism-genome interactions in folate-associated pathologies JO - J Nutr VL - 139 UR - https://doi.org/10.3945/jn.109.113670 DO - 10.3945/jn.109.113670 ID - Stover2009 ER - TY - JOUR AU - Beaudin, A. E. AU - Abarinov, E. V. AU - Noden, D. M. AU - Perry, C. A. AU - Chu, S. AU - Stabler, S. P. PY - 2011 DA - 2011// TI - Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice JO - Am J Clin Nutr VL - 93 UR - https://doi.org/10.3945/ajcn.110.002766 DO - 10.3945/ajcn.110.002766 ID - Beaudin2011 ER - TY - JOUR AU - Fleming, A. AU - Copp, A. J. PY - 1998 DA - 1998// TI - Embryonic folate metabolism and mouse neural tube defects JO - Science VL - 280 UR - https://doi.org/10.1126/science.280.5372.2107 DO - 10.1126/science.280.5372.2107 ID - Fleming1998 ER - TY - JOUR AU - Dunlevy, L. P. AU - Chitty, L. S. AU - Burren, K. A. AU - Doudney, K. AU - Stojilkovic-Mikic, T. AU - Stanier, P. PY - 2007 DA - 2007// TI - Abnormal folate metabolism in foetuses affected by neural tube defects JO - Brain VL - 130 ID - Dunlevy2007 ER - TY - JOUR AU - Copp, A. J. AU - Greene, N. D. PY - 2010 DA - 2010// TI - Genetics and development of neural tube defects JO - J Pathol. VL - 220 ID - Copp2010 ER - TY - JOUR AU - Copp, A. J. AU - Brook, F. A. AU - Estibeiro, J. P. AU - Shum, A. S. AU - Cockroft, D. L. PY - 1990 DA - 1990// TI - The embryonic development of mammalian neural tube defects JO - Prog Neurobiol VL - 35 UR - https://doi.org/10.1016/0301-0082(90)90037-H DO - 10.1016/0301-0082(90)90037-H ID - Copp1990 ER - TY - JOUR AU - Hernandez-Diaz, S. AU - Werler, M. M. AU - Walker, A. M. AU - Mitchell, A. A. PY - 2000 DA - 2000// TI - Folic acid antagonists during pregnancy and the risk of birth defects JO - N Engl J Med VL - 343 UR - https://doi.org/10.1056/NEJM200011303432204 DO - 10.1056/NEJM200011303432204 ID - Hernandez-Diaz2000 ER - TY - JOUR AU - Matok, I. AU - Gorodischer, R. AU - Koren, G. AU - Landau, D. AU - Wiznitzer, A. AU - Levy, A. PY - 2009 DA - 2009// TI - Exposure to folic acid antagonists during the first trimester of pregnancy and the risk of major malformations JO - Br J Clin Pharmacol VL - 68 UR - https://doi.org/10.1111/j.1365-2125.2009.03544.x DO - 10.1111/j.1365-2125.2009.03544.x ID - Matok2009 ER - TY - JOUR AU - Hernandez-Diaz, S. AU - Werler, M. M. AU - Walker, A. M. AU - Mitchell, A. A. PY - 2001 DA - 2001// TI - Neural tube defects in relation to use of folic acid antagonists during pregnancy JO - Am J Epidemiol VL - 153 UR - https://doi.org/10.1093/aje/153.10.961 DO - 10.1093/aje/153.10.961 ID - Hernandez-Diaz2001 ER - TY - JOUR AU - Holmes, L. B. AU - Driscoll, S. G. AU - Atkins, L. PY - 1976 DA - 1976// TI - Etiologic heterogeneity of neural-tube defects JO - N Engl J Med VL - 294 UR - https://doi.org/10.1056/NEJM197602122940704 DO - 10.1056/NEJM197602122940704 ID - Holmes1976 ER - TY - JOUR AU - Detrait, E. R. AU - George, T. M. AU - Etchevers, H. C. AU - Gilbert, J. R. AU - Vekemans, M. AU - Speer, M. C. PY - 2005 DA - 2005// TI - Human neural tube defects: developmental biology, epidemiology, and genetics JO - Neurotoxicol Teratol VL - 27 UR - https://doi.org/10.1016/j.ntt.2004.12.007 DO - 10.1016/j.ntt.2004.12.007 ID - Detrait2005 ER - TY - JOUR AU - Greene, N. D. AU - Stanier, P. AU - Copp, A. J. PY - 2009 DA - 2009// TI - Genetics of human neural tube defects JO - Hum Mol Genet VL - 18 UR - https://doi.org/10.1093/hmg/ddp347 DO - 10.1093/hmg/ddp347 ID - Greene2009 ER - TY - JOUR AU - Chen, C. P. PY - 2007 DA - 2007// TI - Chromosomal abnormalities associated with neural tube defects (II): partial aneuploidy JO - Taiwan J Obstet Gynecol. VL - 46 UR - https://doi.org/10.1016/S1028-4559(08)60003-0 DO - 10.1016/S1028-4559(08)60003-0 ID - Chen2007 ER - TY - JOUR AU - Chen, C. P. PY - 2007 DA - 2007// TI - Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy JO - Taiwan J Obstet Gynecol. VL - 46 UR - https://doi.org/10.1016/S1028-4559(08)60002-9 DO - 10.1016/S1028-4559(08)60002-9 ID - Chen2007 ER - TY - JOUR AU - Harris, M. J. AU - Juriloff, D. M. PY - 2010 DA - 2010// TI - An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure JO - Birth Defects Res A Clin Mol Teratol. VL - 88 UR - https://doi.org/10.1002/bdra.20676 DO - 10.1002/bdra.20676 ID - Harris2010 ER - TY - JOUR AU - Mitchell, L. E. PY - 2005 DA - 2005// TI - Epidemiology of neural tube defects JO - Am J Med Genet C Semin Med Genet. VL - 135C UR - https://doi.org/10.1002/ajmg.c.30057 DO - 10.1002/ajmg.c.30057 ID - Mitchell2005 ER - TY - JOUR AU - Takeuchi, T. AU - Yamazaki, Y. AU - Katoh-Fukui, Y. AU - Tsuchiya, R. AU - Kondo, S. AU - Motoyama, J. PY - 1995 DA - 1995// TI - Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation JO - Genes Dev VL - 9 UR - https://doi.org/10.1101/gad.9.10.1211 DO - 10.1101/gad.9.10.1211 ID - Takeuchi1995 ER - TY - JOUR AU - Schwartz, Y. B. AU - Kahn, T. G. AU - Nix, D. A. AU - Li, X. Y. AU - Bourgon, R. AU - Biggin, M. PY - 2006 DA - 2006// TI - Genome-wide analysis of polycomb targets in Drosophila melanogaster JO - Nat Genet VL - 38 UR - https://doi.org/10.1038/ng1817 DO - 10.1038/ng1817 ID - Schwartz2006 ER - TY - JOUR AU - Endoh, M. AU - Endo, T. A. AU - Endoh, T. AU - Isono, K. AU - Sharif, J. AU - Ohara, O. PY - 2012 DA - 2012// TI - Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity JO - PLoS Genet VL - 8 UR - https://doi.org/10.1371/journal.pgen.1002774 DO - 10.1371/journal.pgen.1002774 ID - Endoh2012 ER - TY - JOUR AU - Welstead, G. G. AU - Creyghton, M. P. AU - Bilodeau, S. AU - Cheng, A. W. AU - Markoulaki, S. AU - Young, R. A. PY - 2012 DA - 2012// TI - X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner JO - Proc Natl Acad Sci USA. VL - 109 UR - https://doi.org/10.1073/pnas.1210787109 DO - 10.1073/pnas.1210787109 ID - Welstead2012 ER - TY - JOUR AU - Schwartz, Y. B. AU - Pirrotta, V. PY - 2007 DA - 2007// TI - Polycomb silencing mechanisms and the management of genomic programmes JO - Nat Rev Genet VL - 8 UR - https://doi.org/10.1038/nrg1981 DO - 10.1038/nrg1981 ID - Schwartz2007 ER - TY - JOUR AU - Partanen, A. AU - Motoyama, J. AU - Hui, C. C. PY - 1999 DA - 1999// TI - Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis JO - Int J Dev Biol VL - 43 ID - Partanen1999 ER - TY - JOUR AU - Blom, H. J. AU - Shaw, G. M. AU - Heijer, M. AU - Finnell, R. H. PY - 2006 DA - 2006// TI - Neural tube defects and folate: case far from closed JO - Nat Rev Neurosci VL - 7 UR - https://doi.org/10.1038/nrn1986 DO - 10.1038/nrn1986 ID - Blom2006 ER - TY - JOUR AU - Gan, Q. AU - Yoshida, T. AU - McDonald, O. G. AU - Owens, G. K. PY - 2007 DA - 2007// TI - Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells JO - Stem Cells. VL - 25 UR - https://doi.org/10.1634/stemcells.2006-0383 DO - 10.1634/stemcells.2006-0383 ID - Gan2007 ER - TY - JOUR AU - Atkinson, S. AU - Armstrong, L. PY - 2008 DA - 2008// TI - Epigenetics in embryonic stem cells: regulation of pluripotency and differentiation JO - Cell Tissue Res VL - 331 UR - https://doi.org/10.1007/s00441-007-0536-x DO - 10.1007/s00441-007-0536-x ID - Atkinson2008 ER - TY - JOUR AU - Ruthenburg, A. J. AU - Li, H. AU - Patel, D. J. AU - Allis, C. D. PY - 2007 DA - 2007// TI - Multivalent engagement of chromatin modifications by linked binding modules JO - Nat Rev Mol Cell Biol VL - 8 UR - https://doi.org/10.1038/nrm2298 DO - 10.1038/nrm2298 ID - Ruthenburg2007 ER - TY - JOUR AU - Bu, P. AU - Evrard, Y. A. AU - Lozano, G. AU - Dent, S. Y. PY - 2007 DA - 2007// TI - Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos JO - Mol Cell Biol VL - 27 UR - https://doi.org/10.1128/MCB.00066-07 DO - 10.1128/MCB.00066-07 ID - Bu2007 ER - TY - JOUR AU - Greene, N. D. AU - Stanier, P. AU - Moore, G. E. PY - 2011 DA - 2011// TI - The emerging role of epigenetic mechanisms in the etiology of neural tube defects JO - Epigenetics. VL - 6 UR - https://doi.org/10.4161/epi.6.7.16400 DO - 10.4161/epi.6.7.16400 ID - Greene2011 ER - TY - JOUR AU - Lin, W. AU - Zhang, Z. AU - Srajer, G. AU - Chen, Y. C. AU - Huang, M. AU - Phan, H. M. PY - 2008 DA - 2008// TI - Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos JO - Dev Dyn VL - 237 UR - https://doi.org/10.1002/dvdy.21479 DO - 10.1002/dvdy.21479 ID - Lin2008 ER - TY - JOUR AU - Barbera, J. P. AU - Rodriguez, T. A. AU - Greene, N. D. AU - Weninger, W. J. AU - Simeone, A. AU - Copp, A. J. PY - 2002 DA - 2002// TI - Folic acid prevents exencephaly in Cited2 deficient mice JO - Hum Mol Genet VL - 11 UR - https://doi.org/10.1093/hmg/11.3.283 DO - 10.1093/hmg/11.3.283 ID - Barbera2002 ER - TY - JOUR AU - Ichi, S. AU - Costa, F. F. AU - Bischof, J. M. AU - Nakazaki, H. AU - Shen, Y. W. AU - Boshnjaku, V. PY - 2010 DA - 2010// TI - Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.126714 DO - 10.1074/jbc.M110.126714 ID - Ichi2010 ER - TY - JOUR AU - Zhang, Q. AU - Bai, B. AU - Mei, X. AU - Wan, C. AU - Cao, H. AU - Dan, L. PY - 2018 DA - 2018// TI - Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects JO - Nat Commun. VL - 9 UR - https://doi.org/10.1038/s41467-018-05451-7 DO - 10.1038/s41467-018-05451-7 ID - Zhang2018 ER - TY - JOUR AU - Xie, Q. AU - Li, C. AU - Song, X. AU - Wu, L. AU - Jiang, Q. AU - Qiu, Z. PY - 2017 DA - 2017// TI - Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription JO - Nucleic Acids Res VL - 45 UR - https://doi.org/10.1093/nar/gkw1208 DO - 10.1093/nar/gkw1208 ID - Xie2017 ER - TY - JOUR AU - Song, J. G. AU - Nakano, S. AU - Ohdo, S. AU - Ogawa, N. PY - 1993 DA - 1993// TI - Chronotoxicity and chronopharmacokinetics of methotrexate in mice: modification by feeding schedule JO - Jpn J Pharmacol VL - 62 UR - https://doi.org/10.1254/jjp.62.373 DO - 10.1254/jjp.62.373 ID - Song1993 ER - TY - JOUR AU - Labat, C. AU - Mansour, K. AU - Malmary, M. F. AU - Terrissol, M. AU - Oustrin, J. PY - 1987 DA - 1987// TI - Chronotoxicity of methotrexate in mice after intraperitoneal administration JO - Chronobiologia. VL - 14 ID - Labat1987 ER - TY - JOUR AU - Olsen, E. A. PY - 1991 DA - 1991// TI - The pharmacology of methotrexate JO - J Am Acad Dermatol VL - 25 UR - https://doi.org/10.1016/0190-9622(91)70199-C DO - 10.1016/0190-9622(91)70199-C ID - Olsen1991 ER - TY - JOUR AU - Pinedo, H. M. AU - Zaharko, D. S. AU - Bull, J. M. AU - Chabner, B. A. PY - 1976 DA - 1976// TI - The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides JO - Cancer Res VL - 36 ID - Pinedo1976 ER - TY - JOUR AU - Chen, Y. AU - Wang, Z. AU - Xie, Y. AU - Guo, X. AU - Tang, X. AU - Wang, S. PY - 2012 DA - 2012// TI - Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells JO - J Neurosci Res VL - 90 UR - https://doi.org/10.1002/jnr.23030 DO - 10.1002/jnr.23030 ID - Chen2012 ER - TY - JOUR AU - Mikkelsen, T. S. AU - Ku, M. AU - Jaffe, D. B. AU - Issac, B. AU - Lieberman, E. AU - Giannoukos, G. PY - 2007 DA - 2007// TI - Genome-wide maps of chromatin state in pluripotent and lineage-committed cells JO - Nature VL - 448 UR - https://doi.org/10.1038/nature06008 DO - 10.1038/nature06008 ID - Mikkelsen2007 ER - TY - JOUR AU - Leeb, M. AU - Wutz, A. PY - 2007 DA - 2007// TI - Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells JO - J Cell Biol VL - 178 UR - https://doi.org/10.1083/jcb.200612127 DO - 10.1083/jcb.200612127 ID - Leeb2007 ER - TY - JOUR AU - Zhou, W. AU - Wang, X. AU - Rosenfeld, M. G. PY - 2009 DA - 2009// TI - Histone H2A ubiquitination in transcriptional regulation and DNA damage repair JO - Int J Biochem Cell Biol VL - 41 UR - https://doi.org/10.1016/j.biocel.2008.09.016 DO - 10.1016/j.biocel.2008.09.016 ID - Zhou2009 ER - TY - JOUR AU - Kouzarides, T. PY - 2007 DA - 2007// TI - Chromatin modifications and their function JO - Cell VL - 128 UR - https://doi.org/10.1016/j.cell.2007.02.005 DO - 10.1016/j.cell.2007.02.005 ID - Kouzarides2007 ER - TY - JOUR AU - Rogakou, E. P. AU - Boon, C. AU - Redon, C. AU - Bonner, W. M. PY - 1999 DA - 1999// TI - Megabase chromatin domains involved in DNA double-strand breaks in vivo JO - J Cell Biol VL - 146 UR - https://doi.org/10.1083/jcb.146.5.905 DO - 10.1083/jcb.146.5.905 ID - Rogakou1999 ER - TY - JOUR AU - Burma, S. AU - Chen, B. P. AU - Murphy, M. AU - Kurimasa, A. AU - Chen, D. J. PY - 2001 DA - 2001// TI - ATM phosphorylates histone H2AX in response to DNA double-strand breaks JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.C100466200 DO - 10.1074/jbc.C100466200 ID - Burma2001 ER - TY - JOUR AU - Ward, I. M. AU - Chen, J. PY - 2001 DA - 2001// TI - Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.C100569200 DO - 10.1074/jbc.C100569200 ID - Ward2001 ER - TY - JOUR AU - Hickson, I. AU - Zhao, Y. AU - Richardson, C. J. AU - Green, S. J. AU - Martin, N. M. AU - Orr, A. I. PY - 2004 DA - 2004// TI - Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-04-2727 DO - 10.1158/0008-5472.CAN-04-2727 ID - Hickson2004 ER - TY - JOUR AU - Gifford, C. A. AU - Ziller, M. J. AU - Gu, H. AU - Trapnell, C. AU - Donaghey, J. AU - Tsankov, A. PY - 2013 DA - 2013// TI - Transcriptional and epigenetic dynamics during specification of human embryonic stem cells JO - Cell VL - 153 UR - https://doi.org/10.1016/j.cell.2013.04.037 DO - 10.1016/j.cell.2013.04.037 ID - Gifford2013 ER - TY - JOUR AU - Harris, M. J. AU - Juriloff, D. M. PY - 2007 DA - 2007// TI - Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects JO - Birth Defects Res A Clin Mol Teratol. VL - 79 UR - https://doi.org/10.1002/bdra.20333 DO - 10.1002/bdra.20333 ID - Harris2007 ER - TY - JOUR AU - Copp, A. J. AU - Greene, N. D. PY - 2013 DA - 2013// TI - Neural tube defects–disorders of neurulation and related embryonic processes JO - Wiley Interdiscip Rev Dev Biol. VL - 2 UR - https://doi.org/10.1002/wdev.71 DO - 10.1002/wdev.71 ID - Copp2013 ER - TY - JOUR AU - Wienken, M. AU - Dickmanns, A. AU - Nemajerova, A. AU - Kramer, D. AU - Najafova, Z. AU - Weiss, M. PY - 2016 DA - 2016// TI - MDM2 Associates with polycomb repressor complex 2 and enhances stemness-promoting chromatin modifications independent of p53 JO - Mol Cell VL - 61 UR - https://doi.org/10.1016/j.molcel.2015.12.008 DO - 10.1016/j.molcel.2015.12.008 ID - Wienken2016 ER -