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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Virtual methylome dissection facilitated by single-cell analyses

Fig. 4

Virtual methylome dissection based on eigen-pCSM loci. a Methylation profiles of eigen-pCSM loci, with each row representing an eigen-pCSM locus and each column representing one synthetic methylome. b Methylation profiles of NMF predicted cell types, with each row representing an eigen-pCSM loci and each column representing an NMF predicted cell type. c Heatmap of cell proportions predicted with NMF across all samples, with each row representing an NMF predicted cell type and each column representing a sample. The proportions were represented by color gradient from blue (low) to red (high). d Clustering analysis of cell types predicted by NMF and 16 reference methylomes. e Recovery of the mixing ratios for 16 neuronal cell types. The reference cell types that could not be unambiguously assigned to an LMC were considered as failures in prediction with a ratio of zero. In each line plot, the synthetic samples are sorted by ascending true mixing proportion

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