Fig. 6

DNA methylation patterns in hippocampus of young and old animals are associated with genes differentially regulated in models of neurodegeneration. a Venn-diagram representing the overlap between genes differentially expressed in two models of neurodegeneration (APP and CK-p25) and genes differentially regulated with aging (males and females combined). Heatmaps illustrating the per-gene gene body methylation patterns of young and old animals (females only) in genes upregulated and downregulated in two models of neurodegeneration (b APP, c CK-p25). Box plots of gene body (d, f) and promoter (e, g) methylation grouped by genes upregulated, unchanged or downregulated in APP (d, e) and CK-p25 (f, g)