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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator

Fig. 5

Proposed model depicting antagonistic effect of Enok on PRC1. a At active trxG target genes, Enok acetylates H3K23 which inhibits PRC1 binding and consequent transcriptional block of RNA-Pol-II. As a consequence, genes remain in an active state. b In the absence of Enok, H3K23 remains unmodified which allows PRC1 recruitment to the chromatin and addition of H2AK118 mono-ubiquitination. Subsequently, PRC1 holds RNA-Pol-II in a stalled state, leading to gene silencing

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