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Table 1 Overlap of 90 pigmentation and melanoma GWAS SNPs with H3K27ac-marked regions and with SOX10 ChIP binding

From: MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

Genomic regions Overlapping GWAS SNPs GWAS-associated phenotypes
H3K27ac-marked regions (DMSO or AZD6244) 70 Hair color, eye color, skin pigmentation, cutaneous melanoma, nevus, freckles, suntan, sunburn, vitiligo
H3K27ac differentially acetylated regions 52 Hair color, eye color, skin pigmentation, cutaneous melanoma, nevus, freckles, suntan, vitiligo
H3K27ac super-enhancers (DMSO or AZD6244) 46 Hair color, eye color, skin pigmentation, cutaneous melanoma, nevus, freckles, suntan, vitiligo
SOX10 ChIP (DMSO or AZD6244) 8 Hair color, eye color, skin pigmentation, cutaneous melanoma, freckles, suntan, sunburn, vitiligo