Skip to main content

Table 2 Down- and upregulated genes in scc1-73 cells are associated with a specific chromatin structure at promoters and cohesin peaks, respectively

From: Crosstalk between chromatin structure, cohesin activity and transcription

 

OPN

promoter

(544)

DPN

promoter

(494)

Closed

promoter

(1646)

Open

promoter

(3586)

FN

promoter

(1953)

SN

promoter

(3066)

RSC-binding

promoter

(239)

Scc2-

binding

promoter

(199)

TATA-containing

(1090)

SAGA-dominated

(577)

TFIID-dominated

(5130)

Mediator-dominated

(315)*

NuA4-

dominated

(500)*

SWR1-

dominated

(462)

Scc1-binding promoter

(2417)

scc1-73 Up-reg. (569)

 Overlap.

57

51

149

373

222

300

15

16

85

50

467

29

92

41

298

 Obs/exp (p val)

1.2

(0.015)

1.2

(0.021)

1.06

(0.026)

1.22

(1.3e−10)

1.34

(3.5e−8)

1.15

(9e−5)

0.74

(0.045)

0.95

(0.1)

0.92

(0.03)

1.02

(0.06)

1.07

(2.1e−4)

1.08

(0.07)

2.25

(1e−14)

1.04

(0.06)

1.45

(4.9e−17)

scc1-73 Down-reg. (445)

 Overlap.

93

27

153

246

212

202

36

15

166

103

307

53

25

48

136

 Obs/exp (p val)

2.56

(8.8e−19)

0.83

(0.017)

1.4

(4.3e−7)

1

(0.03)

1.63

(7.7e−18)

0.99

(0.039)

2.26

(1.5e−6)

1.13

(0.095)

2.29

(4.2e−29)

2.68

(2e−22)

0.9

(2.7e−5)

2.53

(9.8e−11)

0.78

(0.02)

1.56

(5e−4)

0.85

(1.6e3)

  1. The number of genes in each case is indicated in parentheses. The probability of producing the given overlapping if their distributions were random was generated using a hypergeometric test. The rate between the observed and expected frequencies of common genes is also shown. Significantly higher (underlined) and lower (italics) differences (p value < 0.001) are highlighted in bold.
  2. *Only downregulated genes are analyzed. See Additional file 4: Table S4 for list of genes and references