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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence

Fig. 2

Loss of Leo1 causes mis-regulation of heterochromatin. a Mapping of H3K9 methylation in wild-type and leo1∆ cells. The relative fold enrichment of di-methylated H3K9 (log2), as determined by ChIP-chip analysis with two biological replicates, is plotted. bd Box plots showing changes in ChIP-chip signals for H3K9me2 at constitutive heterochromatin loci: the subtelomeric region tel1L (b); the pericentromeric region cen1; and the mating-type locus (d). The centre lines show the medians; the box limits indicate the 25th and 75th percentiles as determined by R software; the whiskers extend 1.5 times the interquartile range from the 25th and 75th percentiles, and outliers are shown. The y-axes show the relative enrichment of H3K9me2. The p values are from independent-samples t-test comparing the mean values between leo1∆ and WT at different time points. (NS) Non-significant; (*) p value < 0.05; (**) p value < 0.01; (***) p value < 0.001

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