TY - JOUR AU - Esposito, K. AU - Chiodini, P. AU - Colao, A. AU - Lenzi, A. AU - Giugliano, D. PY - 2012 DA - 2012// TI - Metabolic syndrome and risk of cancer: a systematic review and meta-analysis JO - Diabetes Care VL - 35 UR - https://doi.org/10.2337/dc12-0336 DO - 10.2337/dc12-0336 ID - Esposito2012 ER - TY - JOUR AU - Hursting, S. D. AU - Digiovanni, J. AU - Dannenberg, A. J. AU - Azrad, M. AU - Leroith, D. AU - Demark-Wahnefried, W. PY - 2012 DA - 2012// TI - Obesity, energy balance, and cancer: new opportunities for prevention JO - Cancer Prev Res (Phila). VL - 5 UR - https://doi.org/10.1158/1940-6207.CAPR-12-0140 DO - 10.1158/1940-6207.CAPR-12-0140 ID - Hursting2012 ER - TY - JOUR AU - Gunter, M. J. AU - Hoover, D. R. AU - Yu, H. AU - Wassertheil-Smoller, S. AU - Rohan, T. E. AU - Manson, J. E. PY - 2009 DA - 2009// TI - Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women JO - J Natl Cancer Inst VL - 101 UR - https://doi.org/10.1093/jnci/djn415 DO - 10.1093/jnci/djn415 ID - Gunter2009 ER - TY - JOUR AU - Lipscombe, L. L. AU - Goodwin, P. J. AU - Zinman, B. AU - McLaughlin, J. R. AU - Hux, J. E. PY - 2006 DA - 2006// TI - Increased prevalence of prior breast cancer in women with newly diagnosed diabetes JO - Breast Cancer Res Treat VL - 98 UR - https://doi.org/10.1007/s10549-006-9166-3 DO - 10.1007/s10549-006-9166-3 ID - Lipscombe2006 ER - TY - JOUR AU - Giudice, M. E. AU - Fantus, I. G. AU - Ezzat, S. AU - McKeown-Eyssen, G. AU - Page, D. AU - Goodwin, P. J. PY - 1998 DA - 1998// TI - Insulin and related factors in premenopausal breast cancer risk JO - Breast Cancer Res Treat VL - 47 UR - https://doi.org/10.1023/A:1005831013718 DO - 10.1023/A:1005831013718 ID - Giudice1998 ER - TY - JOUR AU - Lawlor, D. A. AU - Smith, G. D. AU - Ebrahim, S. PY - 2004 DA - 2004// TI - Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women’s Heart and Health Study JO - Cancer Causes Control VL - 15 UR - https://doi.org/10.1023/B:CACO.0000024225.14618.a8 DO - 10.1023/B:CACO.0000024225.14618.a8 ID - Lawlor2004 ER - TY - JOUR AU - Goodwin, P. J. AU - Ennis, M. AU - Pritchard, K. I. AU - Trudeau, M. E. AU - Koo, J. AU - Taylor, S. K. PY - 2012 DA - 2012// TI - Insulin- and obesity-related variables in early-stage breast cancer: correlations and time course of prognostic associations JO - J Clin Oncol VL - 30 UR - https://doi.org/10.1200/JCO.2011.36.2723 DO - 10.1200/JCO.2011.36.2723 ID - Goodwin2012 ER - TY - JOUR AU - Goodwin, P. J. AU - Ennis, M. AU - Pritchard, K. I. AU - Trudeau, M. E. AU - Koo, J. AU - Madarnas, Y. PY - 2002 DA - 2002// TI - Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study JO - J Clin Oncol VL - 20 UR - https://doi.org/10.1200/JCO.2002.20.1.42 DO - 10.1200/JCO.2002.20.1.42 ID - Goodwin2002 ER - TY - JOUR AU - Carey, L. AU - Winer, E. AU - Viale, G. AU - Cameron, D. AU - Gianni, L. PY - 2010 DA - 2010// TI - Triple-negative breast cancer: disease entity or title of convenience? JO - Nat Rev Clin Oncol. VL - 7 UR - https://doi.org/10.1038/nrclinonc.2010.154 DO - 10.1038/nrclinonc.2010.154 ID - Carey2010 ER - TY - JOUR AU - Pierobon, M. AU - Frankenfeld, C. L. PY - 2013 DA - 2013// TI - Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis JO - Breast Cancer Res Treat VL - 137 UR - https://doi.org/10.1007/s10549-012-2339-3 DO - 10.1007/s10549-012-2339-3 ID - Pierobon2013 ER - TY - JOUR AU - Huang, J. AU - Morehouse, C. AU - Streicher, K. AU - Higgs, B. W. AU - Gao, J. AU - Czapiga, M. PY - 2011 DA - 2011// TI - Altered expression of insulin receptor isoforms in breast cancer JO - PLoS ONE VL - 6 UR - https://doi.org/10.1371/journal.pone.0026177 DO - 10.1371/journal.pone.0026177 ID - Huang2011 ER - TY - JOUR AU - Belfiore, A. AU - Frasca, F. AU - Pandini, G. AU - Sciacca, L. AU - Vigneri, R. PY - 2009 DA - 2009// TI - Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease JO - Endocr Rev VL - 30 UR - https://doi.org/10.1210/er.2008-0047 DO - 10.1210/er.2008-0047 ID - Belfiore2009 ER - TY - JOUR AU - Calle, E. E. AU - Kaaks, R. PY - 2004 DA - 2004// TI - Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms JO - Nat Rev Cancer VL - 4 UR - https://doi.org/10.1038/nrc1408 DO - 10.1038/nrc1408 ID - Calle2004 ER - TY - JOUR AU - Benito, M. AU - Valverde, A. M. AU - Lorenzo, M. PY - 1996 DA - 1996// TI - IGF-I: a mitogen also involved in differentiation processes in mammalian cells JO - Int J Biochem Cell Biol VL - 28 UR - https://doi.org/10.1016/1357-2725(95)00168-9 DO - 10.1016/1357-2725(95)00168-9 ID - Benito1996 ER - TY - JOUR AU - Saltiel, A. R. AU - Kahn, C. R. PY - 2001 DA - 2001// TI - Insulin signalling and the regulation of glucose and lipid metabolism JO - Nature VL - 414 UR - https://doi.org/10.1038/414799a DO - 10.1038/414799a ID - Saltiel2001 ER - TY - JOUR AU - Engelman, J. A. AU - Luo, J. AU - Cantley, L. C. PY - 2006 DA - 2006// TI - The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism JO - Nat Rev Genet VL - 7 UR - https://doi.org/10.1038/nrg1879 DO - 10.1038/nrg1879 ID - Engelman2006 ER - TY - JOUR AU - Manning, B. D. AU - Cantley, L. C. PY - 2007 DA - 2007// TI - AKT/PKB signaling: navigating downstream JO - Cell VL - 129 UR - https://doi.org/10.1016/j.cell.2007.06.009 DO - 10.1016/j.cell.2007.06.009 ID - Manning2007 ER - TY - JOUR AU - Morita, M. AU - Gravel, S. P. AU - Chenard, V. AU - Sikstrom, K. AU - Zheng, L. AU - Alain, T. PY - 2013 DA - 2013// TI - mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation JO - Cell Metab VL - 18 UR - https://doi.org/10.1016/j.cmet.2013.10.001 DO - 10.1016/j.cmet.2013.10.001 ID - Morita2013 ER - TY - JOUR AU - Belfiore, A. AU - Frittitta, L. AU - Costantino, A. AU - Frasca, F. AU - Pandini, G. AU - Sciacca, L. PY - 1996 DA - 1996// TI - Insulin receptors in breast cancer JO - Ann N Y Acad Sci VL - 784 UR - https://doi.org/10.1111/j.1749-6632.1996.tb16235.x DO - 10.1111/j.1749-6632.1996.tb16235.x ID - Belfiore1996 ER - TY - JOUR AU - Mathieu, M. C. AU - Clark, G. M. AU - Allred, D. C. AU - Goldfine, I. D. AU - Vigneri, R. PY - 1997 DA - 1997// TI - Insulin receptor expression and clinical outcome in node-negative breast cancer JO - Proc Assoc Am Physicians VL - 109 ID - Mathieu1997 ER - TY - JOUR AU - Campbell, I. G. AU - Russell, S. E. AU - Choong, D. Y. AU - Montgomery, K. G. AU - Ciavarella, M. L. AU - Hooi, C. S. PY - 2004 DA - 2004// TI - Mutation of the PIK3CA gene in ovarian and breast cancer JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-04-2933 DO - 10.1158/0008-5472.CAN-04-2933 ID - Campbell2004 ER - TY - JOUR AU - Vivanco, I. AU - Sawyers, C. L. PY - 2002 DA - 2002// TI - The phosphatidylinositol 3-kinase AKT pathway in human cancer JO - Nat Rev Cancer VL - 2 UR - https://doi.org/10.1038/nrc839 DO - 10.1038/nrc839 ID - Vivanco2002 ER - TY - JOUR AU - Guertin, D. A. AU - Sabatini, D. M. PY - 2007 DA - 2007// TI - Defining the role of mTOR in cancer JO - Cancer Cell VL - 12 UR - https://doi.org/10.1016/j.ccr.2007.05.008 DO - 10.1016/j.ccr.2007.05.008 ID - Guertin2007 ER - TY - JOUR AU - Hynes, N. E. AU - Boulay, A. PY - 2006 DA - 2006// TI - The mTOR pathway in breast cancer JO - J Mammary Gland Biol Neoplasia VL - 11 UR - https://doi.org/10.1007/s10911-006-9012-6 DO - 10.1007/s10911-006-9012-6 ID - Hynes2006 ER - TY - JOUR AU - Ueng, S. H. AU - Chen, S. C. AU - Chang, Y. S. AU - Hsueh, S. AU - Lin, Y. C. AU - Chien, H. P. PY - 2012 DA - 2012// TI - Phosphorylated mTOR expression correlates with poor outcome in early-stage triple negative breast carcinomas JO - Int J Clin Exp Pathol VL - 5 ID - Ueng2012 ER - TY - JOUR AU - Novosyadlyy, R. AU - Lann, D. E. AU - Vijayakumar, A. AU - Rowzee, A. AU - Lazzarino, D. A. AU - Fierz, Y. PY - 2010 DA - 2010// TI - Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes JO - Cancer Res VL - 70 UR - https://doi.org/10.1158/0008-5472.CAN-09-2141 DO - 10.1158/0008-5472.CAN-09-2141 ID - Novosyadlyy2010 ER - TY - JOUR AU - Ferguson, R. D. AU - Novosyadlyy, R. AU - Fierz, Y. AU - Alikhani, N. AU - Sun, H. AU - Yakar, S. PY - 2012 DA - 2012// TI - Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes JO - Breast Cancer Res VL - 14 UR - https://doi.org/10.1186/bcr3089 DO - 10.1186/bcr3089 ID - Ferguson2012 ER - TY - JOUR AU - Gallagher, E. J. AU - Alikhani, N. AU - Tobin-Hess, A. AU - Blank, J. AU - Buffin, N. J. AU - Zelenko, Z. PY - 2013 DA - 2013// TI - Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptor JO - Diabetes VL - 62 UR - https://doi.org/10.2337/db13-0249 DO - 10.2337/db13-0249 ID - Gallagher2013 ER - TY - JOUR AU - Vander Heiden, M. G. AU - Cantley, L. C. AU - Thompson, C. B. PY - 2009 DA - 2009// TI - Understanding the Warburg effect: the metabolic requirements of cell proliferation JO - Science VL - 324 UR - https://doi.org/10.1126/science.1160809 DO - 10.1126/science.1160809 ID - Vander Heiden2009 ER - TY - JOUR AU - Su, X. AU - Wellen, K. E. AU - Rabinowitz, J. D. PY - 2016 DA - 2016// TI - Metabolic control of methylation and acetylation JO - Curr Opin Chem Biol VL - 30 UR - https://doi.org/10.1016/j.cbpa.2015.10.030 DO - 10.1016/j.cbpa.2015.10.030 ID - Su2016 ER - TY - JOUR AU - Cerbo, V. AU - Schneider, R. PY - 2013 DA - 2013// TI - Cancers with wrong HATs: the impact of acetylation JO - Brief Funct Genomics VL - 12 UR - https://doi.org/10.1093/bfgp/els065 DO - 10.1093/bfgp/els065 ID - Cerbo2013 ER - TY - JOUR AU - Reid, M. A. AU - Dai, Z. AU - Locasale, J. W. PY - 2017 DA - 2017// TI - The impact of cellular metabolism on chromatin dynamics and epigenetics JO - Nat Cell Biol VL - 19 UR - https://doi.org/10.1038/ncb3629 DO - 10.1038/ncb3629 ID - Reid2017 ER - TY - JOUR AU - Zelenko, Z. AU - Gallagher, E. J. AU - Antoniou, I. M. AU - Sachdev, D. AU - Nayak, A. AU - Yee, D. PY - 2016 DA - 2016// TI - EMT reversal in human cancer cells after IR knockdown in hyperinsulinemic mice JO - Endocr Relat Cancer VL - 23 UR - https://doi.org/10.1530/ERC-16-0142 DO - 10.1530/ERC-16-0142 ID - Zelenko2016 ER - TY - JOUR AU - Shlomai, G. AU - Zelenko, Z. AU - Antoniou, I. M. AU - Stasinopoulos, M. AU - Tobin-Hess, A. AU - Vitek, M. P. PY - 2017 DA - 2017// TI - OP449 inhibits breast cancer growth without adverse metabolic effects JO - Endocr Relat Cancer VL - 24 UR - https://doi.org/10.1530/ERC-17-0077 DO - 10.1530/ERC-17-0077 ID - Shlomai2017 ER - TY - JOUR AU - Orlando, D. A. AU - Chen, M. W. AU - Brown, V. E. AU - Solanki, S. AU - Choi, Y. J. AU - Olson, E. R. PY - 2014 DA - 2014// TI - Quantitative ChIP-Seq normalization reveals global modulation of the epigenome JO - Cell Rep VL - 9 UR - https://doi.org/10.1016/j.celrep.2014.10.018 DO - 10.1016/j.celrep.2014.10.018 ID - Orlando2014 ER - TY - JOUR AU - Love, M. I. AU - Huber, W. AU - Anders, S. PY - 2014 DA - 2014// TI - Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 JO - Genome Biol VL - 15 UR - https://doi.org/10.1186/s13059-014-0550-8 DO - 10.1186/s13059-014-0550-8 ID - Love2014 ER - TY - JOUR AU - Zhu, J. AU - Blenis, J. AU - Yuan, J. PY - 2008 DA - 2008// TI - Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1 JO - Proc Natl Acad Sci USA VL - 105 UR - https://doi.org/10.1073/pnas.0802785105 DO - 10.1073/pnas.0802785105 ID - Zhu2008 ER - TY - JOUR AU - Witkiewicz, A. K. AU - Kline, J. AU - Queenan, M. AU - Brody, J. R. AU - Tsirigos, A. AU - Bilal, E. PY - 2011 DA - 2011// TI - Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers JO - Cell Cycle VL - 10 UR - https://doi.org/10.4161/cc.10.11.15675 DO - 10.4161/cc.10.11.15675 ID - Witkiewicz2011 ER - TY - JOUR AU - Hur, K. Y. AU - Lee, M. S. PY - 2015 DA - 2015// TI - New mechanisms of metformin action: focusing on mitochondria and the gut JO - J Diabetes Investig VL - 6 UR - https://doi.org/10.1111/jdi.12328 DO - 10.1111/jdi.12328 ID - Hur2015 ER - TY - JOUR AU - Lee, J. V. AU - Berry, C. T. AU - Kim, K. AU - Sen, P. AU - Kim, T. AU - Carrer, A. PY - 2018 DA - 2018// TI - Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca(2+)-NFAT signaling JO - Genes Dev VL - 32 UR - https://doi.org/10.1101/gad.311027.117 DO - 10.1101/gad.311027.117 ID - Lee2018 ER - TY - JOUR AU - Kurdistani, S. K. PY - 2014 DA - 2014// TI - Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology JO - Curr Opin Genet Dev VL - 26 UR - https://doi.org/10.1016/j.gde.2014.06.002 DO - 10.1016/j.gde.2014.06.002 ID - Kurdistani2014 ER - TY - JOUR AU - Gallagher, E. J. AU - LeRoith, D. PY - 2010 DA - 2010// TI - The proliferating role of insulin and insulin-like growth factors in cancer JO - Trends Endocrinol Metab VL - 21 UR - https://doi.org/10.1016/j.tem.2010.06.007 DO - 10.1016/j.tem.2010.06.007 ID - Gallagher2010 ER - TY - JOUR AU - Law, J. H. AU - Habibi, G. AU - Hu, K. AU - Masoudi, H. AU - Wang, M. Y. AU - Stratford, A. L. PY - 2008 DA - 2008// TI - Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-08-2755 DO - 10.1158/0008-5472.CAN-08-2755 ID - Law2008 ER - TY - JOUR AU - Papa, V. AU - Pezzino, V. AU - Costantino, A. AU - Belfiore, A. AU - Giuffrida, D. AU - Frittitta, L. PY - 1990 DA - 1990// TI - Elevated insulin receptor content in human breast cancer JO - J Clin Invest VL - 86 UR - https://doi.org/10.1172/JCI114868 DO - 10.1172/JCI114868 ID - Papa1990 ER - TY - JOUR AU - Frasca, F. AU - Pandini, G. AU - Scalia, P. AU - Sciacca, L. AU - Mineo, R. AU - Costantino, A. PY - 1999 DA - 1999// TI - Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells JO - Mol Cell Biol VL - 19 UR - https://doi.org/10.1128/MCB.19.5.3278 DO - 10.1128/MCB.19.5.3278 ID - Frasca1999 ER - TY - JOUR AU - Gliozzo, B. AU - Sung, C. K. AU - Scalia, P. AU - Papa, V. AU - Frasca, F. AU - Sciacca, L. PY - 1998 DA - 1998// TI - Insulin-stimulated cell growth in insulin receptor substrate-1-deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway JO - J Cell Biochem VL - 70 UR - https://doi.org/3.0.CO;2-J DO - 3.0.CO;2-J ID - Gliozzo1998 ER - TY - JOUR AU - Gugneja, S. AU - Scarpulla, R. C. PY - 1997 DA - 1997// TI - Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding JO - J Biol Chem VL - 272 UR - https://doi.org/10.1074/jbc.272.30.18732 DO - 10.1074/jbc.272.30.18732 ID - Gugneja1997 ER - TY - JOUR AU - Kinnaird, A. AU - Zhao, S. AU - Wellen, K. E. AU - Michelakis, E. D. PY - 2016 DA - 2016// TI - Metabolic control of epigenetics in cancer JO - Nat Rev Cancer VL - 16 UR - https://doi.org/10.1038/nrc.2016.82 DO - 10.1038/nrc.2016.82 ID - Kinnaird2016 ER - TY - JOUR AU - Cluntun, A. A. AU - Huang, H. AU - Dai, L. AU - Liu, X. AU - Zhao, Y. AU - Locasale, J. W. PY - 2015 DA - 2015// TI - The rate of glycolysis quantitatively mediates specific histone acetylation sites JO - Cancer Metab VL - 3 UR - https://doi.org/10.1186/s40170-015-0135-3 DO - 10.1186/s40170-015-0135-3 ID - Cluntun2015 ER - TY - JOUR AU - Lee, J. V. AU - Carrer, A. AU - Shah, S. AU - Snyder, N. W. AU - Wei, S. AU - Venneti, S. PY - 2014 DA - 2014// TI - Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation JO - Cell Metab VL - 20 UR - https://doi.org/10.1016/j.cmet.2014.06.004 DO - 10.1016/j.cmet.2014.06.004 ID - Lee2014 ER - TY - JOUR AU - Carrer, A. AU - Trefely, S. AU - Zhao, S. AU - Campbell, S. L. AU - Norgard, R. J. AU - Schultz, K. C. PY - 2019 DA - 2019// TI - Acetyl-CoA metabolism supports multistep pancreatic tumorigenesis JO - Cancer Discov VL - 9 UR - https://doi.org/10.1158/2159-8290.CD-18-0567 DO - 10.1158/2159-8290.CD-18-0567 ID - Carrer2019 ER - TY - JOUR AU - Chio, I. I. C. AU - Tuveson, D. A. PY - 2017 DA - 2017// TI - ROS in cancer: the burning question JO - Trends Mol Med VL - 23 UR - https://doi.org/10.1016/j.molmed.2017.03.004 DO - 10.1016/j.molmed.2017.03.004 ID - Chio2017 ER - TY - JOUR AU - Kumari, S. AU - Badana, A. K. AU - G, M. M. AU - G, S. AU - Malla, R. PY - 2018 DA - 2018// TI - Reactive oxygen species: a key constituent in cancer survival JO - Biomark Insights VL - 13 UR - https://doi.org/10.1177/1177271918755391 DO - 10.1177/1177271918755391 ID - Kumari2018 ER - TY - JOUR AU - Waris, G. AU - Ahsan, H. PY - 2006 DA - 2006// TI - Reactive oxygen species: role in the development of cancer and various chronic conditions JO - J Carcinog VL - 5 UR - https://doi.org/10.1186/1477-3163-5-14 DO - 10.1186/1477-3163-5-14 ID - Waris2006 ER - TY - JOUR AU - Hu, C. M. AU - Tien, S. C. AU - Hsieh, P. K. AU - Jeng, Y. M. AU - Chang, M. C. AU - Chang, Y. T. PY - 2019 DA - 2019// TI - High glucose triggers nucleotide imbalance through O-GlcNAcylation of key enzymes and induces KRAS mutation in pancreatic cells JO - Cell Metab. VL - 29 UR - https://doi.org/10.1016/j.cmet.2019.02.005 DO - 10.1016/j.cmet.2019.02.005 ID - Hu2019 ER - TY - JOUR AU - Langmead, B. AU - Trapnell, C. AU - Pop, M. AU - Salzberg, S. L. PY - 2009 DA - 2009// TI - Ultrafast and memory-efficient alignment of short DNA sequences to the human genome JO - Genome Biol VL - 10 UR - https://doi.org/10.1186/gb-2009-10-3-r25 DO - 10.1186/gb-2009-10-3-r25 ID - Langmead2009 ER -