TY - JOUR AU - Senapati, Parijat AU - Kato, Hiroyuki AU - Lee, Michael AU - Leung, Amy AU - Thai, Christine AU - Sanchez, Angelica AU - Gallagher, Emily J. AU - LeRoith, Derek AU - Seewaldt, Victoria L. AU - Ann, David K. AU - Schones, Dustin E. PY - 2019 DA - 2019/07/17 TI - Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer JO - Epigenetics & Chromatin SP - 44 VL - 12 IS - 1 AB - Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream effector of insulin, enhances mitochondrial biogenesis and activity, thereby increasing acetyl-CoA precursors. Increased acetyl-CoA can, in turn, be utilized by nuclear acetyltransferases for histone acetylation, a critical feature of genome regulation. While signaling pathways downstream of insulin have been established for sometime, the effect of insulin on chromatin remains unclear. We hypothesized that hyperinsulinemia-induced metabolic changes lead to genome-wide changes in histone acetylation in TNBC. SN - 1756-8935 UR - https://doi.org/10.1186/s13072-019-0290-9 DO - 10.1186/s13072-019-0290-9 ID - Senapati2019 ER -