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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

Fig. 1

BET proteins displacement from chromatin is compound dose dependent. a Proliferation assays in sensitive (MV4;11) and resistant (K562) cells treated with increasing concentrations of I-BET151. Compound IC50 (M) or compound concentration which induces 50% inhibition of cell viability as well as the response area (see “Materials and methods” section for the calculation) is shown below the graph. b Experimental design followed in the study and I-BET151 structure. c Bar plot showing the ChIP-qPCR enrichment relative to DMSO for the ZC3H4 locus in K562 and MV4;11 for cells treated with three concentrations of I-BET151 and DMSO as a control. d Barplot showing the number of peaks called for BRD4 at TSS for cells treated with three concentrations of I-BET151 and DMSO as a control and for both cell lines

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Epigenetics & Chromatin

ISSN: 1756-8935