Fig. 4
Changes in both X-chromosomal and global levels of H3K27me3 in female PGCs require PRDM14 but are independent of each other. Relationship between X-chromosomal (bar graphs, % of PGCs per genotype) and global (pie charts, % of PGCs per genotype within each H3K27me3 spot/no spot sub-category) levels of H3K27me3 in PGCs from female embryos of different Prdm14 genotypes. Chi-square test was used to compare dependency of global of H3K27me3 upregulation on X-chromosomal removal for each Prdm14 genotype (n.s., not significant; Prdm14+/+ p = 0.956, Prdm14+/− p = 0.499, Prdm14−/− p = 0.091)