Fig. 3
Erasure of H3K27me3-enrichment from the inactive X-chromosome in migrating female PGCs is dependent on PRDM14. a Representative images of AP2γ-positive PGCs with the presence or absence of H3K27me3 accumulation (H3K27me3 spot, white arrowheads) on the inactive X-chromosome. PGC nuclei are outlined in the H3K27me3 channel. Scale bar: 10 µm. b Percentage of H3K27me3 spot-positive and spot-negative PGCs across Prdm14 genotypes. Labels in each column indicate number of cells analyzed. c Erasure of the H3K27me3-spot in PGCs of different Prdm14 genotypes during their migration along the hindgut divided in four quadrants (Q1–Q4). Labels in each column indicate number of PGCs analyzed. Chi-square test was used for statistical comparisons (p < 0.001)