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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Aberrant methylation-mediated downregulation of lncRNA SSTR5-AS1 promotes progression and metastasis of laryngeal squamous cell carcinoma

Fig. 5

SSTR5-AS1 upregulates SSTR5 expression through interacting with MLL3. a Overexpression of SSTR5-AS1 increased mRNA expression level of SSTR5 in AMC-HN-8 cells. *P < 0.05. b Overexpression of SSTR5-AS1 increased protein expression level of SSTR5 in AMC-HN-8 cells. c RIP assay showed the binding of SSTR5-AS1 to MLL3 in SSTR5-AS1-transfected AMC-HN-8 cells. *P < 0.05. d Co-expression of SSTR5-AS1 and MLL3 had a synergistic promoting effect on the mRNA up regulation of SSTR5. *P < 0.05. e Co-expression of SSTR5-AS1 and MLL3 had a synergistic promoting effect on the protein overexpression of SSTR5. f ChIP assay revealed that overexpression of SSTR5-AS1 increased the enrichment of MLL3 and the level of H3K4me3 at the promoter region of SSTR5. *Compared with empty vector, P < 0.05. g The expression level of SSTR5 was positively correlated with MLL3 in HNSC in LinkedOmics dataset

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Epigenetics & Chromatin

ISSN: 1756-8935