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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Aberrant methylation-mediated downregulation of lncRNA SSTR5-AS1 promotes progression and metastasis of laryngeal squamous cell carcinoma

Fig. 4

Functional analysis of SSTR5-AS1 in human laryngeal carcinoma cells. a Subcellular localization of SSTR5-AS1 in various cells predicted by lncATLAS. b Expression levels of SSTR5-AS1 in nuclear and cytoplasmic fractions of TU212 and TU686 cells detected by qRT-PCR method. GAPDH: cytoplasmic control; U6: nuclear control. c Significant upregulation of SSTR5-AS1 was detected by qRT-PCR in SSTR5-AS1-transfected AMC-HN-8 and TU177 cells. *Compared with empty vector transfected cells, P < 0.05. d Over-expression of SSTR5-AS1 inhibited AMC-HN-8 and TU177 cells proliferation. *Compared with empty vector, P < 0.05. e Over-expression of SSTR5-AS1 inhibited AMC-HN-8 and TU177 cells colony formation ability. *Compared with empty vector, P < 0.05. f Over-expression of SSTR5-AS1 inhibited AMC-HN-8 and TU177 cells migration ability. *Compared with empty vector, P < 0.05. g Over-expression of SSTR5-AS1 inhibited AMC-HN-8 and TU177 cells invasion ability. *Compared with empty vector, P < 0.05

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