Fig. 1

Differential chromatin accessibility in p63 mutant keratinocytes. a A heatmap of sample correlation matrix showing high similarities between duplicates and dissimilarities between control (CTR) and p63 mutant keratinocytes (R204W and R304W). b PCA plots of ATAC-seq and RNA-seq of control and p63 mutant keratinocytes at the proliferation stage. c Upper panel, volcano plots of ATAC-seq comparisons between control and p63 mutant keratinocytes. The x axis shows the log2 fold change of reads detected at the open chromatin regions (OCRs) and the y axis shows − log10 (p value). Lower panel, the transcriptional changes of differentially expressed genes associated with differential OCRs indicated in the volcano plots. d GO annotation of differentially expressed genes nearby Ctr-OCRs and Mt-OCRs. e Examples of Ctr-OCRs and their associated DE gene, CDC7, as well as Mt-OCRs and their associated DE gene, FAP. ATAC-seq tracks are shown in the RPKM scale