Fig. 4

Chromatin states at DMCs are enriched for enhancers, and loss of methylation is enriched for regions that become more active during differentiation. a Emission parameters of the nine chromatin states learned using ChromHMM. b Enrichment analysis of DMCs based on chromatin states for monocytes (left) and macrophages (right) for gain and loss of methylation compared to genome-wide chromatin states. c Enrichment of gain over loss for each of the transitions from monocyte (x-axis) to macrophage (y-axis). b, c are plotted in log2 scale