Fig. 3

Variant nucleosomes are associated with distinct regulatory elements and genic features in KDM5B-depleted ES cells. a, b Schema of + 1 nucleosomes relative to transcriptional start site (TSS) shifted a downstream or b upstream. c, d Semantic similarity of GO functional annotation terms [35] enriched by GREAT [34] software for shifted c + 1 nucleosomes or d − 1 nucleosomes. Heatmaps represent semantic similarity calculated for the following sets: genes with + 1 or − 1 nucleosomes shifted by 0, 1–9, 10–51, 51–100, 101–150, or 151–200 bp in KDM5B-depleted ES cells. The three most enriched GO categories for each cluster are shown on the right. Color scale: red indicates high