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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: The BAF complex in development and disease

Fig. 3

The role of subunit mutations in cancer. Mutations in BAF subunit do not only cause neurodevelopmental diseases but also have an important role in tumorigenesis. Genome-wide sequencing revealed that about 20% of human cancers show BAF subunit mutations; amongst the most frequently mutated subunits is BAF250a. Like BAF complex composition unique to some tissue types, many mutations have a “unique” pattern of malignancies they play a role in

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