Fig. 3From: The BAF complex in development and diseaseThe role of subunit mutations in cancer. Mutations in BAF subunit do not only cause neurodevelopmental diseases but also have an important role in tumorigenesis. Genome-wide sequencing revealed that about 20% of human cancers show BAF subunit mutations; amongst the most frequently mutated subunits is BAF250a. Like BAF complex composition unique to some tissue types, many mutations have a “unique” pattern of malignancies they play a role inBack to article page