Fig. 4From: Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicingKnockdown of PARP1 induces dynamic changes in the occupancy of histone marks. The occupancy of activating histone marks (H3K4me3; lower panels of a, b) at AKAP200 (a) and CAPER (b), and the occupancy of the repressive histone marks (H3K27me3) at AKAP200 (c) and CAPER (d) were evaluated by ChIP-qPCR for PARP1 target genes. All experiments were performed in triplicate, and results are presented as mean ± SD (p value < 0.05). Statistical significance was tested by Student’s t test methodBack to article page