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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states

Fig. 3

Misexpression of imprinted genes in EpiSC-NTs and EpiSC-PGAs. a Example of tag-normalized RNA-seq data over imprinted genes in EpiSCs. A further extension of this example is shown in Additional file 2: Fig. S10. b Quantification of expression levels (RPKM) of the genes shown in Fig. 2a. The individual replicas of all samples are included in the graph, but not individually labeled. “P” = paternally expressed; “M” = maternally expressed. Additional file 2: Fig. S15 additionally includes quantification of expression levels of the B6D2F1 embryonic tissues. c Average fold change in gene expression in EpiSC-PGAs as compared to fertilized EpiSCs. Statistically significant changes (adjusted p value < 0.05) are indicated with a asterisk. A detailed genome browser view for Snrpn/Snurf and D7Ertd715e is shown in a. Besides imprinted genes included in Fig. 2a, this panel additionally includes all other known imprinted genes differentially expressed between EpiSCs and EpiSC-PGAs (Additional file 7: Table S6)

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