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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups

Fig. 2

Chromatin remodellers bind to distinct regions of chromatin in two defined groups. a Percentage of all 60,043 remodeller binding sites in each chromHMM chromatin state compiled into active promoters (promoters and flanking promoters), transcription (strong and weak and at 5′/3′ ends of genes), active enhancers (genic and other enhancers), bivalent (enhancers, promoters, and flanking promoters), repressive (polycomb, weak polycomb, zinc finger repeats and heterochromatin), and unmarked (no core marks from the Roadmap Epigenome chromatin state model). b Schematic diagram of histone modifications present at ‘active’ and ‘repressive’ promoters and enhancers. ‘Active’ histone modifications are shown in green with increased spacing between nucleosomes, while ‘repressive’ histone modifications are shown in red with compacted nucleosomes. cg, i Enrichment of chromatin remodeller binding sites at key gene regulatory features defined by ‘active’ and ‘repressive’ histone modifications. Significant enrichment is defined as a score above one and significantly depleted as below one with Benjamini–Hochberg adj p value, ***p < 0.001 or **p < 0.05. h Genome browser view of chromatin remodeller occupancy and key histone modification tracks in LNCaP cells showing upstream of the SDC1 promoter and at the COPS4 promoter, which is occupied by all Group 1 remodellers and adjacent to exon 2 in COPS4 that is occupied by all Group 2 remodellers

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