Fig. 2

Methylation levels (a–d) of and the enrichment of DMS sites (e–h) on four types of neuronal activity-associated enhancers. Neuronal activity-associated enhancers with CBP/H3K4me1 marks were classified into four groups, according to the changes of H3K27ac upon KCl stimulation: constant H3K27ac, increasing H3K27ac, decreasing H3K27ac and no H3K27ac. In a–d, confidence band for each line represents the average of methylation level ± S.E.M. The y-axis in a–d denotes the methylation level, and the y-axis in e, f denotes the frequency of DMSs identified in pairwise comparisons surrounding enhancers normalized to the genome average