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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition

Fig. 6

Comprehensive histone PTM analysis during EMT. a Workflow for label-free quantification of histone PTMs. b Number of identified histone peptides carrying different types of modifications at indicated TGF-β stimulation times with biological triplicates. c Three-dimensional PCA (principal component analysis) representing histone PTM types was clustered separately based on different stimulation times. The data supplied to generate PCA were all detected histone peptides provided in Table S3A, including modified and unmodified peptides. d Volcano plot presenting fold change and significance of histone H3 and H4 single PTMs relative abundance. Yellow bubbles are significantly regulated marks, i.e., with a t test p value < 0.05 or > 4.32 when − log2 transformed. e Relative abundance changes of selected single histone PTMs. Error bars represent standard deviation (n = 3)

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