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Table 1 WD-specific liver DMRs with genome-wide significance and associated genes

From: Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers

Chr Start End CpGs Methylation difference (%) FWER Gene Distance to TSS (kb) Position
chr21 31557558 31560049 156 − 37 < 0.001 TIAM1 0.0 TSS
       LOC150051 0.0 TSS
chr12 3199472 3201083 96 − 35 0.004 TSPAN9 122.1 Intron
       PRMT8 − 180.3 Upstream
chr9 136050881 136052939 57 − 35 0.008 NACC2 42.3 Intron
       UBAC1 − 89.5 Upstream
chr22 27797270 27798795 87 27 0.018 MN1 2.7 Exon
       LOC100507657 486.6 Downstream
chr15 99105435 99106614 93 − 13 0.020 SYNM 0.4 Exon
       LRRC28 − 144.7 Upstream
chr18 22171324 22172395 66 − 27 0.023 GATA6-AS1 − 2.4 Upstream
chr21 44456208 44457837 56 29 0.023 LRRC3 0.7 Exon
       LRRC3-AS1 − 0.9 Upstream
chr20 40691316 40693007 60 − 28 0.025 MAFB − 2.1 Upstream
chr9 137461602 137462399 37 − 28 0.028 NSMF − 2.3 Upstream
chr9 136418051 136418847 29 32 0.031 SDCCAG3 − 7.4 Upstream
       INPP5E 21.0 Downstream
chr11 66855700 66857160 56 − 32 0.032 LRFN4 − 0.2 Upstream
chr22 39994424 39995559 72 − 24 0.035 FAM83F 0.0 TSS
chr4 15702770 15703332 32 − 28 0.038 BST1 0.0 TSS
chr14 37597362 37599120 65 − 17 0.038 FOXA1 − 2.2 Upstream
chr16 30604376 30605260 48 29 0.043 ZNF689 5.5 Exon
       ZNF785 − 18.6 Upstream
chr17 28371994 28372583 59 − 20 0.044 SARM1 0.3 Exon
       VTN − 1.6 Upstream
chr9 121772727 121773248 32 23 0.048 DAB2IP 205.6 Exon
       TTLL11 320.4 Downstream
chr5 10649279 10650004 64 18 0.049 ANKRD33B 85.0 Exon
       DAP 111.3 Downstream
  1. FWER, family-wise error rate