Table 1 WD-specific liver DMRs with genome-wide significance and associated genes
Chr | Start | End | CpGs | Methylation difference (%) | FWER | Gene | Distance to TSS (kb) | Position |
|---|---|---|---|---|---|---|---|---|
chr21 | 31557558 | 31560049 | 156 | − 37 | < 0.001 | TIAM1 | 0.0 | TSS |
LOC150051 | 0.0 | TSS | ||||||
chr12 | 3199472 | 3201083 | 96 | − 35 | 0.004 | TSPAN9 | 122.1 | Intron |
PRMT8 | − 180.3 | Upstream | ||||||
chr9 | 136050881 | 136052939 | 57 | − 35 | 0.008 | NACC2 | 42.3 | Intron |
UBAC1 | − 89.5 | Upstream | ||||||
chr22 | 27797270 | 27798795 | 87 | 27 | 0.018 | MN1 | 2.7 | Exon |
LOC100507657 | 486.6 | Downstream | ||||||
chr15 | 99105435 | 99106614 | 93 | − 13 | 0.020 | SYNM | 0.4 | Exon |
LRRC28 | − 144.7 | Upstream | ||||||
chr18 | 22171324 | 22172395 | 66 | − 27 | 0.023 | GATA6-AS1 | − 2.4 | Upstream |
chr21 | 44456208 | 44457837 | 56 | 29 | 0.023 | LRRC3 | 0.7 | Exon |
LRRC3-AS1 | − 0.9 | Upstream | ||||||
chr20 | 40691316 | 40693007 | 60 | − 28 | 0.025 | MAFB | − 2.1 | Upstream |
chr9 | 137461602 | 137462399 | 37 | − 28 | 0.028 | NSMF | − 2.3 | Upstream |
chr9 | 136418051 | 136418847 | 29 | 32 | 0.031 | SDCCAG3 | − 7.4 | Upstream |
INPP5E | 21.0 | Downstream | ||||||
chr11 | 66855700 | 66857160 | 56 | − 32 | 0.032 | LRFN4 | − 0.2 | Upstream |
chr22 | 39994424 | 39995559 | 72 | − 24 | 0.035 | FAM83F | 0.0 | TSS |
chr4 | 15702770 | 15703332 | 32 | − 28 | 0.038 | BST1 | 0.0 | TSS |
chr14 | 37597362 | 37599120 | 65 | − 17 | 0.038 | FOXA1 | − 2.2 | Upstream |
chr16 | 30604376 | 30605260 | 48 | 29 | 0.043 | ZNF689 | 5.5 | Exon |
ZNF785 | − 18.6 | Upstream | ||||||
chr17 | 28371994 | 28372583 | 59 | − 20 | 0.044 | SARM1 | 0.3 | Exon |
VTN | − 1.6 | Upstream | ||||||
chr9 | 121772727 | 121773248 | 32 | 23 | 0.048 | DAB2IP | 205.6 | Exon |
TTLL11 | 320.4 | Downstream | ||||||
chr5 | 10649279 | 10650004 | 64 | 18 | 0.049 | ANKRD33B | 85.0 | Exon |
DAP | 111.3 | Downstream |