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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers

Fig. 6

Blood DMRs distinguish patients with hepatic (H) or neurologic (N) WD. DMRs differentiating WDH from WDN were identified. a Heatmap using methylation in WDH versus WDN blood DMRs. Percent methylation for each sample relative to the mean methylation at each DMR is plotted (WDH n = 20, WDN n = 20). b Principal component analysis using methylation in WDH versus WDN blood DMRs. Ellipses show 95% confidence intervals. c Results from GREAT functional enrichment analysis of WDH versus WDN blood DMRs compared to background. Terms from gene ontology databases with FDR q < 0.05 are shown, with a dotted line indicating the significance threshold. “All DMRs” (green) refers to both hypermethylated and hypomethylated DMRs; “Hypomethylated DMRs” (blue) refers to DMRs with lower methylation in WDH compared to WDN

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