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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers

Fig. 3

WD-specific hypermethylated liver DMRs are enriched in liver-associated transcription factor binding sites. a WD liver DMRs were overlapped with available liver transcription factor ChIP-seq peaks from ENCODE using LOLA and the odds ratio was plotted and sorted by hypermethylated DMR odds ratio. b WD liver DMR sequences were tested for enriched known transcription factor motifs using HOMER and factors with liver ChIP-seq data were plotted. c Hypermethylated WD liver DMRs overlapping with top liver transcription factor ChIP-seq peaks were overlapped. d Transcription factor overlap enrichment. e UCSC Genome Browser view of overlapping transcription factor binding sites and a hypermethylated DMR at LRRC3

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