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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming

Fig. 2

Chronic preconception male ethanol exposure exerts sex-specific effects on offspring metabolic function. a Fasting blood glucose levels compared between preconception treatments (n = 15 males, 15 females). b Fasting insulin levels compared between preconception treatments (n = nine males, nine females). cf Glucose tolerance (GTT) and insulin tolerance (ITT) tests in the offspring of ethanol-exposed and control males (n = 15 males, 15 females). Organ weights of g male and h female offspring compared between the two preconception treatment groups (n = nine males, nine females). i Representative immunoblot comparing total and phosphorylated AKT (Ser473) between male and female offspring sired by ethanol-exposed and control males (n = six males and six females). j Densitometry analysis of immunoblots comparing total and phosphorylated AKT (n = six males and six females). Data analyzed using either an unpaired t test or a two-way ANOVA followed by Sidak post hoc analysis. Error bars represent SEM *p < 0.05 and **p < 0.01 (comparisons between alcohol and control preconception treatments)

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