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Fig. 9 | Epigenetics & Chromatin

Fig. 9

From: The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region

Fig. 9

Schematic model of the mechanism by which Kcnq1ot1 regulates p57 expression during muscle differentiation. In undifferentiated cells Kcnq1ot1 recruits EZH2 and promotes H3K27me3 accumulation on the p57 intragenic region (p57i). Upon differentiation stimuli, the decrease in EZH2 binding and H3K27me3 levels allows the interaction of MyoD and, conceivably, other cofactors with the same region and with Kcnq1ot1, leading to the induction of p57 expression

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