Fig. 3
From: Histone H3 lysine K4 methylation and its role in learning and memory
Enzymology of H3K4 methylation and demethylation. a Evolutionary tree diagram of H3K4 methyltransferases from yeast (S. cerevisiae) to flies (D. melanogaster) to humans (H. sapiens). b Diagram of H3K4 methylation and demethylation reaction pathways. Mono-, di-, and trimethylation reactions are carried out by all members of the KMT2 family. H3K4me1 and H3K4me2 demethylation reactions are carried out by KDM1 and KDM5 family members. The H3K4me3 demethylation reaction is carried out by KDM5 family members. c Bubble diagram of COMPASS-like complexes formed with each KMT2 family member. Methyltransferase subunits (gray) associate with a core WRAD complex comprised of WDR5, RBP5, ASH2L, and DPY-30 (blue). Additional subunits (green) associate with specific COMPASS-like complexes to influence target selection. d Table of H3K4 methyltransferase/demethylase enzymes and alternative names used in the literature