Table 1 List of consensus motifs corresponding to known transcription factors significantly enriched in the set of differential histone-modified regions that are associated with P. falciparum infection
From: Chromatin changes in Anopheles gambiae induced by Plasmodium falciparum infection
Histone | Motif | P values | % Targets/background | TF BS predicted (score) | FlyBase record | Function |
|---|---|---|---|---|---|---|
H3K9ac | CGTTCCCYWTTT | 1E−23 | 18.40/1.06 | kni/dmmpmm/fly (0.64) | http://flybase.org/reports/FBgn0001320 | Development, gene expression |
AACKATTT | 1E−23 | 18.40/1.02 | br-Z2/dmmpmm/fly (0.727) | Development, gene expression, reproduction, response to stimulus | ||
GTGCGTRA | 1E−23 | 18.40/1.20 | z/dmmpmm/fly (0.71) | Gene expression, nucleus | ||
GCGATAGA | 1E−21 | 20.80/1.68 | Dref/dmmpmm/fly (0.75) | Development, gene expression, metabolism | ||
MCCGAGCN | 1E−20 | 16.00/0.64 | Deaf1/dmmpmm/fly (0.70) | Immune system, development, gene expression | ||
TAATCCRY | 1E−19 | 16.00/0.93 | Gsc/dmmpmm/fly (0.88) | Gene expression, other molecular function | ||
CATCCTGGCG | 1E−17 | 24.00/3.41 | brk/dmmpmm/fly (0.679) | Development, gene expression, signaling, response to stimulus | ||
TCCTTCGA | 1E−15 | 17.60/2.23 | ttk/dmmpmm/fly (0.71) | Development, reproduction, response to stimulus, cell organization–biogenesis | ||
CTTGTTCTTC | 1E−15 | 13.60/0.58 | pan/dmmpmm/fly (0.63) | Signaling, gene expression, immune system | ||
TTCGTAATAC | 1E−15 | 13.60/1.46 | gt/dmmpmm/fly (0.66) | Development, gene expression, transcription factor | ||
GCTTGCTY | 1E−14 | 16.80/2.34 | grh/dmmpmm/fly (0.72) | Development, biogenesis | ||
AGCTTTAA | 1E−12 | 15.70/2.29 | zen/dmmpmm/fly (0.70) | Development, gene expression, transcription factor | ||
H3K27ac | GGCTCGTC | 1E−29 | 11.74/0.43 | h/dmmpmm/fly(0.676) | Development, gene expression, DNA binding | |
ATTTTTCCCC | 1E−21 | 9.39/0.65 | dl/dmmpmm/fly (0.69) | Immune system, development, gene expression | ||
AGAACAGTAA | 1E−21 | 9.39/0.40 | ara/dmmpmm/fly (0.67) | Development, gene expression | ||
GTGCAGCTCG | 1E−21 | 9.39/0.65 | sna/dmmpmm/fly (0.65) | Development, gene expression, DNA binding | ||
CAAAAACGCAAC | 1E−21 | 9.39/0.67 | hb/dmmpmm/fly (0.744) | Development, gene expression, transcription factor | ||
CTATGTTT | 1E−16 | 9.86/0.84 | pan/dmmpmm/fly (0.80) | Signaling, gene expression, immune system | ||
TCGATCGTCG | 1E−15 | 7.51/0.00 | Dref/dmmpmm/fly (0.60) | Development, gene expression, DNA binding, transcription factor, cell cycle, DNA metabolism | ||
ATWTCTGC | 1E−13 | 8.45/1.00 | grh/dmmpmm/fly (0.714) | Development, biogenesis | ||
CTTCADTGCGGA | 1E−13 | 6.57/0.66 | slbo/dmmpmm/fly (0.661) | Development, gene expression, reproduction | ||
CACGAAGT | 1E− 12 | 12.68/2.32 | Eip74EF/dmmpmm/fly (0.772) | Development, reproduction | ||
H3K4me3 | ARTTTTGTGT | 1E−30 | 5.16/0.27 | br-Z3/dmmpmm/fly (0.70) | Development, gene expression, reproduction, response to stimuli | |
TTTGATTCGTAA | 1E−30 | 5.16/0.28 | ara/dmmpmm/fly (0.67) | Development, gene expression | ||
CTTCTTGCCCGA | 1E−23 | 5.34/0.49 | Eip74EF/dmmpmm/fly (0.62) | Development, gene expression, reproduction | ||
CGAARAAGAR | 1E−18 | 5.34/0.56 | pan/dmmpmm/fly (0.70) | Development, gene expression, response to stimulus, signaling, immune system | ||
TCCTCGTCGTTG | 1E−16 | 7.55/1.60 | Aef1/dmmpmm/fly (0.56) | Other molecular function | ||
H3K9me3 | AGCGCCTGGT | 1E−26 | 8.82/0.61 | brk/dmmpmm/fly (0.688) | Development, gene expression, response to stimulus, signaling | |
YCTGTGACCG | 1E−24 | 8.46/0.59 | Hth/dmmpmm/fly (0.72) | Development, gene expression, DNA binding, transport/localization, transcription facto | ||
TCYKGWAKCKGA | 1E−24 | 8.46/0.58 | Pnt/dmmpmm/fly (0.60) | Development, gene expression, response to stimulus, signaling, immune system, cell cycle/proliferation, DNA binding | ||
ACTCCAGATA | 1E−21 | 7.72/0.57 | z/dmmpmm/fly (0.61) | Development, gene expression, protein metabolism, cell organization/biogenesis, enzyme | ||
CTAYTTAT | 1E−21 | 7.72/0.18 | bin/dmmpmm/fly (0.829) | Development, gene expression, transcription factor | ||
ATCTCGGG | 1E−21 | 7.72/0.53 | Deaf1/dmmpmm/fly (0.68) | Development, gene expression, immune system, response to stimulus, transcription factor | ||
CATTCGAC | 1E−21 | 9.56/0.81 | sd/dmmpmm/fly (0.70) | Development, gene expression, other molecular function, DNA binding, cell cycle/proliferation | ||
RCGAAATTTTTG | 1E−20 | 7.35/0.22 | cad/dmmpmm/fly (0.76) | Development, gene expression, response to stimulus, transcription factor, DNA binding, immune system | ||
TTAGACGA | 1E−20 | 7.35/0.40 | exd/dmmpmm/fly (0.67) | Development, gene expression, other molecular function, DNA binding, transcription factor |