Fig. 4

Tissue-specific MHBs resembled the regulatory elements for tissue identity. a Heatmap representing the enrichment of H3K4me1 and H3k27ac relative to the shared MHBs with low MHL in adult tissues, mouse embryonic stem cells and the whole brain tissue from E14.5 embryo. b The enrichment of H3K4me1 and H3k27ac relative to the shared MHBs with high MHL and tissue-specific MHBs. c Transcriptional factor binding motif enrichments near tissue-specific MHBs. d, e The IPA analyses of the genes overlapped with tissue-specific MHBs found canonical pathways and diseases significantly affected. f Lollipop plots showing the 5mC and 5hmC modification of co-hyroxymethylation of neighboring CpGs of a DNA molecule (or a sequencing read) within cerebellum-specific MHBs