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Fig. 8 | Epigenetics & Chromatin

Fig. 8

From: Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination

Fig. 8

TET1 and TET2 differentially bind to adipogenic gene regions. BMSC were cultured under normal growth (Cont) or adipogenic (Adipo) conditions and then processed for chromatin extraction. Recruitment of TET molecules to genomic regions was assessed by chromatin immunoprecipitation and normalised to the genomic input control. a Relative enrichment of TET1 on PPARγ2 transcription start site (TSS), exon and intron regions. b Relative enrichment of TET1 on ADIPSIN TSS, exon and intron regions. c Relative enrichment of TET2 on PPARγ2 TSS, exon and intron regions. d Relative enrichment of TET2 on ADIPSIN TSS, exon and intron regions. Data represent mean S.E.M., n = 3 BMSC donors, *p ≤ 0.05, one-way ANOVA with multiple comparison analyses

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